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补锌对缺锌大鼠烧伤后肠道细菌移位及毒血症的影响

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邱振中　李锐　

摘　要：目的:探讨补锌对大鼠烧伤后肠道细菌移位及毒血症的影响.方法:90只SD大鼠进食低锌饲料(含锌量:1.6ug·g-1)1周,造成缺锌模型,并随机分为正常对照组(A)、烧伤对照组(B)、烧伤治疗组(C).B组和C组造成20%总体表面积Ⅲ度烧伤.B组伤后继续进食低锌饲料,C组伤后进食正常含锌饲料(含锌量:24.7ug·g-1).采用甲基-3H胸腺嘧啶核苷([3H]-TdR)标记致病大肠杆菌,在烧伤前注入大鼠的胃肠道.在不同的时象点,检测血浆内毒素(LPS)含量、血和肝的3H放射活性.结果:(1)B、C组3H的放射活性和血浆LPS含量显著高于A组(P＜0.05);同时,C组显著低于B组(P＜0.05).(2)B、C组肝的3H放射活性比A组显著增高(P＜0.05),C组比B组低.结论:烧伤后补锌能减轻大鼠肠道细菌移位及毒血症.
关键词：烧伤;锌;细菌移位;毒血症
分类号：R644;R631.1　文献标识码：A
文章编号：1001-0726(2005)03-0190-04

The effect of zinc supplements on enteral bacterial translocation and toxemia in rats after burn

QIU Zhen-zhong　 LI Rui　

作者简介：邱振中(1973～),男(汉族),安徽阜南人,1995年第二军医大学毕业,主治医师.
作者简介：李锐(1973～),女(汉族),甘肃兰州人,1995年兰州军区医学高等专科学校毕业,主管护师.
作者单位：邱振中（中国人民解放军第三医院烧伤科,陕西,宝鸡,721004）　
　　　　　李锐（中国人民解放军第三医院烧伤科,陕西,宝鸡,721004）　

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