大鼠烫伤后肠壁微血管通透性和肠组织含水量的变化

摘　要：目的:观察大鼠烫伤后12h肠壁微血管通透性和肠组织含水量变化,探讨烫伤早期肠粘膜损伤的可能机制.方法:制作成年大鼠严重烫伤模型(Ⅲ度,30%TBSA),在未烫伤鼠及烫伤后12h应用分光光度法测量肠壁微血管通透性,测量回肠组织含水量.结果:对照组肠壁微血管对伊文思蓝有一定的通透性(12.39±5.062μg/g),烫伤后12h肠壁微血管对伊文思蓝通透性较对照组低(10.50±2.031μg/g),但无统计学意义(t=0.923,P>0.05);对照组回肠含水量为83.3±3.8%,烫伤后12h肠组织含水量比对照组稍低(82.9±1.5%),也无统计学意义(t=0.278,P>0.05).结论:烫伤早期肠壁微血管通透性和肠组织含水量无显著变化,提示炎症介质在烫伤早期肠粘膜损伤中可能不是主要致病因子.
关键词：烫伤;血管通透性;伊文思蓝
分类号：R644;R644;R574.53　文献标识码：A
文章编号：1001-0726(2005)02-0094-03

基金项目：江西省自然科学基金资助项目(基金编号0340059)
作者简介：邵立健(1974～),男(汉族),江西都昌人,2001年江西医学院研究生毕业,博士,讲师.
作者简介：朱清仙(1955～),男(汉族),江西南昌人,1977年江西医学院毕业,教授.
作者单位：邵立健（江西医学院解剖学教研室,江西,南昌,330006）　
　　　　　朱清仙（江西医学院组织胚胎学教研室,江西,南昌,330006）　

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