钟克勤 马恩庆 钟克勤 马恩庆
摘 要:目的:探讨血浆内皮素(ET)变化与烧伤早期心肌损害的关系。方法:采用放免法检测5例严重烧伤病人烧伤早期血浆ET和ASCA仪测定血浆肌酸激酶同工酶(CK-MB)。结果:伤后12h血浆ET(106.0±1.6pg/ml,n=5)较正常人组(47.6±3.4pg/ml,n=8)明显升高。血浆CK-MB在伤后明显升高。相关分析显示,ET升高与CK-MB呈高度正相关。结论:血浆ET升高可能参与了烧伤早期的心肌损害。
关键词:内皮素;肌酸激酶同工酶;严重烧伤;心肌损害
分类号:R644;R363 文献标识码:A
文章编号:1001-0726(2001)01-0042-03
A Preliminary Study of the Relationship between Plasma Endothelin Level and Myocardial Damage at the Early Stage of Severe Burn
ZHONG Ke-qin(Dept. of Burn and Plastic surgery, Xiangya Hospital, Medical College of Central-South University, Changsha, Hunan 410008)
MA En-qing(Dept. of Burn and Plastic surgery, Xiangya Hospital, Medical College of Central-South University, Changsha, Hunan 410008)
ZHONG Ke-qin(Dept. of Burn and Plastic surgery, Xiangya Hospital, Medical College of Central-South University, Changsha, Hunan 410008)
MA En-qing(Dept. of Burn and Plastic surgery, Xiangya Hospital, Medical College of Central-South University, Changsha, Hunan 410008)
Abstract:Objective: To study the effect of plasma endothelin (ET) level on myocardial injury of severely burned patients. Method: Plasma ET level was determined by radio-immunoassay and plasma levels of CK-MB by automatic serum biochemical assay. Result: Plasma ET level increased significantly 12 hr post burn as compared with normal persons (P<0.01), plasma CK-MB increased significantly within first 24 hr post burn. Plasma ET level was positive correlated to CK-MB level. Conclusion: The results suggested that elevated plasma ET level may be involved in the damage of myocardium in the early stage of severe burn.
Keywords:Endothelin; CK-MB; Myocardial injury; Burn
作者简介:钟克勤(1963-),男(汉族),湖南桃源人,主治医师. 马恩庆(1934-),男(回族),河北定县人,教授
作者单位:钟克勤(中南大学医学际湘雅医院烧伤科 湖南长沙 410008)
马恩庆(中南大学医学际湘雅医院烧伤科 湖南长沙 410008)
钟克勤(杨州大学医学院附院江苏杨州 225001)
马恩庆(杨州大学医学院附院江苏杨州 225001)
参考文献:
[1]唐朝枢,李兆萍,樊贵,等.内皮素对离体大鼠心肌细胞的影响.生理学报,1991,44(1):15.
[2]唐朝枢,佟利家,樊贵,等.内皮素对大鼠心肌乳酸转运的影响.北京医科大学学报,1991,23(2):83.
[3]李怀斌,刘力生.内皮素对离体灌注心脏的冠脉和心功能的影响.中国循环杂志,1992,7(2):83.
[4]黄跃生,黎鳌,杨宗城.烧伤病人心肌损害及其机理的临床探讨.中华整形烧伤外科杂志,1993,9(2):99.